The high quality and volume of cardiac CT scans made at our site, creates the opportunity to gather a great amount of research data. Currently several research projects are coupled to the cardiac CT.


Velthuis S, Laufer EM, Hofstra L, Winkens MH. An armored heart in constrictive pericarditis. J Am Coll Cardiol 2009;53:972.

Winkens MH, Snoep G, Bekkers SC. Images in cardiovascular medicine. Imaging of arrhythmogenic right ventricular cardiomyopathy. Circulation 2008;118:e158-9.


1. Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State.

Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BL.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):2032-2040. Epub 2013 Jul 1.

PMID: 23818485 [PubMed – as supplied by publisher]

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2. Additive value of semiautomated quantification of coronary artery disease using cardiac computed tomographic angiography to predict future acute coronary syndrome.

Versteylen MO, Kietselaer BL, Dagnelie PC, Joosen IA, Dedic A, Raaijmakers RH, Wildberger JE, Nieman K, Crijns HJ, Niessen WJ, Daemen MJ, Hofstra L.

J Am Coll Cardiol. 2013 Jun 4;61(22):2296-305. doi: 10.1016/j.jacc.2013.02.065. Epub 2013 Apr 3.

PMID: 23562925 [PubMed – in process]

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3. Accelerated in vivo thrombin formation independently predicts the presence and severity of CT angiographic coronary atherosclerosis.

Borissoff JI, Joosen IA, Versteylen MO, Spronk HM, ten Cate H, Hofstra L.

JACC Cardiovasc Imaging. 2012 Dec;5(12):1201-10. doi: 10.1016/j.jcmg.2012.01.023.

PMID: 23236969 [PubMed – indexed for MEDLINE]

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4. Relation between mild to moderate chronic kidney disease and coronary artery disease determined with coronary CT angiography.

Joosen IA, Schiphof F, Versteylen MO, Laufer EM, Winkens MH, Nelemans PJ, Kooman JP, Hofstra L, Wildberger JE, Leiner T.

PLoS One. 2012;7(10):e47267. doi: 10.1371/journal.pone.0047267. Epub 2012 Oct 10.

PMID: 23071773 [PubMed – indexed for MEDLINE] Free PMC Article

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5. Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype.

Schurgers LJ, Joosen IA, Laufer EM, Chatrou ML, Herfs M, Winkens MH, Westenfeld R, Veulemans V, Krueger T, Shanahan CM, Jahnen-Dechent W, Biessen E, Narula J, Vermeer C, Hofstra L, Reutelingsperger CP.

PLoS One. 2012;7(8):e43229. doi: 10.1371/journal.pone.0043229. Epub 2012 Aug 29.

PMID: 22952653 [PubMed – indexed for MEDLINE] Free PMC Article

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6. Patients originally diagnosed with idiopathic atrial fibrillation more often suffer from insidious coronary artery disease compared to healthy sinus rhythm controls.

Weijs B, Pisters R, Haest RJ, Kragten JA, Joosen IA, Versteylen M, Timmermans CC, Pison L, Blaauw Y, Hofstra L, Nieuwlaat R, Wildberger J, Crijns HJ.

Heart Rhythm. 2012 Dec;9(12):1923-9. doi: 10.1016/j.hrthm.2012.08.013. Epub 2012 Aug 8.

PMID: 22885921 [PubMed – indexed for MEDLINE]

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7. Letter in response to Andrea K.Y. Lee et al. “normalcy rate of computed tomographic coronary angiography”.

Joosen IA, Versteylen MO, Das M, Kietselaer BL.

Int J Cardiol. 2012 Jul 12;158(2):299-300. doi: 10.1016/j.ijcard.2012.04.116. Epub 2012 May 12. No abstract available.

PMID: 22584074 [PubMed – indexed for MEDLINE]

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8. High-sensitivity cardiac troponin T: risk stratification tool in patients with symptoms of chest discomfort.

Mingels AM, Joosen IA, Versteylen MO, Laufer EM, Winkens MH, Wildberger JE, Van Dieijen-Visser MP, Hofstra L.

PLoS One. 2012;7(4):e35059. doi: 10.1371/journal.pone.0035059. Epub 2012 Apr 25.

PMID: 22558116 [PubMed – indexed for MEDLINE] Free PMC Article

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9. Epicardial adipose tissue volume as a predictor for coronary artery disease in diabetic, impaired fasting glucose, and non-diabetic patients presenting with chest pain.

Versteylen MO, Takx RA, Joosen IA, Nelemans PJ, Das M, Crijns HJ, Hofstra L, Leiner T.

Eur Heart J Cardiovasc Imaging. 2012 Jun;13(6):517-23. doi: 10.1093/ehjci/jes024. Epub 2012 Feb 5.

PMID: 22312037 [PubMed – indexed for MEDLINE]

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10. Combined use of exercise electrocardiography, coronary calcium score and cardiac CT angiography for the prediction of major cardiovascular events in patients presenting with stable chest pain.

Versteylen MO, Joosen IA, Winkens MH, Laufer EM, Snijder RJ, Wildberger JE, Crijns HJ, Narula J, Hofstra L.

Int J Cardiol. 2013 Jul 15;167(1):121-5. doi: 10.1016/j.ijcard.2011.12.016. Epub 2012 Jan 5.

PMID: 22225760 [PubMed – in process]

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11. Comparison of Framingham, PROCAM, SCORE, and Diamond Forrester to predict coronary atherosclerosis and cardiovascular events.

Versteylen MO, Joosen IA, Shaw LJ, Narula J, Hofstra L.

J Nucl Cardiol. 2011 Oct;18(5):904-11. doi: 10.1007/s12350-011-9425-5. Epub 2011 Jul 19.

PMID: 21769703 [PubMed – indexed for MEDLINE] Free PMC Article

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12. Monocoronary system with malignant course of the LAD.

Versteylen M, Joosen I, Hofstra L.

Heart. 2010 Jul;96(13):1049. doi: 10.1136/hrt.2010.198184. No abstract available.

PMID: 20584858 [PubMed – indexed for MEDLINE]

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13. The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T.

Laufer EM, Mingels AM, Winkens MH, Joosen IA, Schellings MW, Leiner T, Wildberger JE, Narula J, Van Dieijen-Visser MP, Hofstra L.

Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1269-75. doi: 10.1161/ATVBAHA.109.200394. Epub 2010 Mar 18.

PMID: 20299689 [PubMed – indexed for MEDLINE] Free Article

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